1. Identify lifestyle and environmental factors linked to human health

• Qi W^#, Mei Z^#, Sun Z, Lin C, Lin J, Li J, Ji JS^*, Zheng Y^*. Exposure to Multiple Air Pollutants and the Risk of Fractures: A Large Prospective Population-Based Study. J Bone Miner Res. 2023 Nov;38(11):1549-1559.
• Hu J, Zhao M, Lin C, Sun Z, Chen GC, Mei Z^*, Zheng Y^*. Associations of visceral adipose tissue with bone mineral density and fracture: observational and Mendelian randomization studies. Nutr Metab (Lond). 2022 Jul 12;19(1):45.

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2. Discover biomarkers and predictors for diseases

• Mei Z^#, Xu L^#, Huang Q^#, Lin C^#, Yu M, Shali S, Wu H, Lu Y, Wu R, Wang Z, Luo L, Sun Z, Sun L, Qian J, Chen G, Tang H, Yao K^*, Zheng Y^*, Dai Y^*, Ge J. Metabonomic Biomarkers of Plaque Burden and Instability in Patients With Coronary Atherosclerotic Disease After Moderate Lipid-Lowering Therapy. J Am Heart Assoc. 2024 Dec 17.
• Mei Z^#, Wang F^#, Bhosle A, Dong D, Mehta R, Ghazi A, Zhang Y, Liu Y, Rinott E, Ma S, Rimm EB, Daviglus M, Willett WC, Knight R, Hu FB, Qi Q, Chan AT, Burk RD, Stampfer MJ, Shai I, Kaplan RC, Huttenhower C^*, Wang DD^*. Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes. Nat Med. 2024 Jun 25.
• Mei Z, Yin MT, Sharma A, Wang Z, Peters BA, Chandran A, Weber KM, Ross RD, Gustafson D, Zheng Y, Kaplan RC, Burk RD, Qi Q. Gut microbiota and plasma metabolites associated with bone mineral density in women with or at risk of HIV infection. AIDS. 2023 Jan 1;37(1):149-159.
• Lin C^#, Sun Z^#, Mei Z^#, Zeng H, Zhao M, Hu J, Xia M, Huang T, Wang C, Gao X, Zheng Y. The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study. BMC Med. 2022 Oct 28;20(1):414.
• Mei Z^#, Dong X^#, Qian Y^#, Hong D, Xie Z, Yao G, Qin A, Gao S, Hu J, Liang L^*, Zheng Y^*, Su J^*. Association between the metabolome and bone mineral density in a Chinese population. EBioMedicine. 2020 Dec;62:103111.

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3. Decipher the mechanism underlying the association of risk factors with diseases and validate these findings through in vivo and in vitro studies

• Mei Z, Chen GC, Wang Z, Usyk M, Yu B, Baeza YV, Humphrey G, Benitez RS, Li J, Williams-Nguyen JS, Daviglus ML, Hou L, Cai J, Zheng Y, Knight R, Burk RD, Boerwinkle E, Kaplan RC, Qi Q. Dietary factors, gut microbiota, and serum trimethylamine-N-oxide associated with cardiovascular disease in the Hispanic Community Health Study/Study of Latinos. Am J Clin Nutr. 2021 Jun 1;113(6):1503-1514. [With editorial]

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4. Generate scientific evidence supporting precision medicine

• Mei Z, Chen GC, Hu J, Lin C, Sun Z, Liu C, Geng X, Yuan C, Qi Q, Zheng Y. Habitual use of fish oil supplements, genetic predisposition, and risk of fractures: a large population-based study. Am J Clin Nutr. 2021 Sep 1;114(3):945-954.

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5. Pinpoint potential targets for intervention